As some commentators have pointed out, it appears that it was particularly Jesus' engagement with the demonic that was causing Mary and Jesus' brothers to arch their eyebrows the sharpest. It all seemed a little bizarre to them. In verse 21 they say literally that they had to get him on home because Jesus was exeste, a word meaning to stand outside of yourself. Even today we may refer to a person who is an emotional wreck as being "beside himself" with grief. The idea is that someone has taken leave of his senses (or his senses have taken leave of him) and so what remains for the time being is a person whose emotions are unchecked and unregulated. This is the family's assessment of Jesus.
Apparently…
ChristianGlobe Networks, Inc. , Comments and Observations, by Scott Hoezee